在 1,011 个Saccharomyces cerevisiae分离物中基因组的演变
Jackson Peter1, Matteo De Chiara2, Anne Friedrich1
1Université de Strasbourg, CNRS, GMGM UMR 7156, Strasbourg, France.
Nature
|April 13, 2018
概括
这项研究对1011种Saccharomyces cerevisiae (面包酵母) 的基因组进行了测序,揭示了它们的进化历史和遗传变异. 主要发现包括亚洲起源,化事件以及遗传变化对酵母特征的影响.
科学领域:
- 基因组学
- 进化生物学
- 微生物学
背景情况:
- 人口基因组调查对于理解自然种群的表型多样性至关重要.
- 细菌菌作为研究酵母进化和变化的模型生物.
研究的目的:
- 进行 1,011 个Saccharomyces cerevisiae分离物的全基因组测序和表型.
- 阐明形成S. cerevisiae表型景观的进化历史和基因组变异.
- 为未来的人口基因组学和基因型-表型研究提供资源.
主要方法:
- 1,011个Saccharomyces cerevisiae分离物的全基因组测序.
- 测序分离物的表型.
- 基因组分析,包括变种识别和关联研究.
主要成果:
- 基因组分析支持S. cerevisiae的单一"中国外"起源,随后发生多次化事件.
- 化分离物在化,无化和基因组含量方面具有很高的变异性,而野生分离物主要通过单核酸多态 (SNP) 进化.
- 广泛的异构性损失是常见的特征,有助于个体间的变化. 副本数量的变化比SNP具有更大的表型效应.
结论:
- 这项研究提供了对影响S. cerevisiae表型的基因组变异的准确进化图片.
- 这一全面的数据集是促进这种模型酵母群体基因组学和基因型-表型研究的宝贵资源.
- 了解S. cerevisiae表型多样性的遗传基础对基础研究和应用微生物学都有影响.
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