不对称的化物A合成:用于氧化合的化物阻断组的战略性使用
Xiaowei Wu1, Takayuki Iwata1, Adam Scharf1
1Department of Chemistry and Center for Molecular Discovery (BU-CMD) , Boston University , Boston , Massachusetts 02215 , United States.
Journal of the American Chemical Society
|April 17, 2018
概括
研究人员首次合成了克罗曼乳二聚甲基. 这涉及瓦纳介导的氧化合和动态分离策略,使化合成不对称.
科学领域:
- 有机化学
- 合成方法
- 自然产品合成
背景情况:
- 酸乳是一种具有潜在生物活性的天然产品.
- 综合复杂的二维结构,如化物A提出了重大挑战.
- 有效的动力分辨率和不对称的合成方法对于获得质纯化合物至关重要.
研究的目的:
- 开发第一个合成路径到chromanone乳二聚甲基.
- 探索中介氧化合在二聚体形成中的实用性.
- 建立基尼托利德A及其形体的动态分辨率和不对称合成的策略.
主要方法:
- 中介性氧化合的单体化物C.
- 应用一个正阻断组策略来控制区域选择性 (对对合).
- 不对称的结合降解以获得赛米前体的动力分辨率和不对称的合成.
主要成果:
- 首次成功合成化物A.
- 通过阻断组策略证明了区域选择性对对合.
- 实现了一种性,血性前体的实际动态分辨率
- 对 (+) - 化物A及其化物进行选择性合成.
结论:
- 开发的中介氧化合提供了有效的化物A路径.
- 在区域控制和运动分辨率方面,正氧阻断组策略是关键.
- 不对称的结合降解是一种可行的方法,用于获取enantiopure gonytolide A及其基体.
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