饮酒风险值:对83项前性研究中的599,912名饮酒者个人数据的综合分析
Angela M Wood1, Stephen Kaptoge1, Adam S Butterworth1
1Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Lancet (London, England)
|April 21, 2018
概括
每周喝100克或更少的酒精与所有原因死亡率和心血管疾病的风险最低. 更高的酒精消耗显著减少了预期寿命,增加了中风和心力衰竭的风险.
科学领域:
- 心脏病学
- 流行病学
- 公共卫生
背景情况:
- 每个国家的饮酒准则各不相同.
- 确定最佳的低风险饮酒门对于公共健康至关重要.
- 之前的研究没有明确地确定酒精含量限制以尽量减少死亡率和心血管疾病 (CVD) 风险.
研究的目的:
- 确定与所有原因死亡率和心血管疾病的最低风险相关的酒精消费门.
- 在一个大群体中分析酒精摄入量与健康结果之间的剂量反应关系.
- 提供最新的国家和国际饮酒指南.
主要方法:
- 来自83项前性研究的个人参与者数据分析 (599,912名当前饮酒者).
- 每周酒精摄入量 (克/周) 和死亡率/心血管疾病事件之间的特征剂量反应关系.
- 对吸烟,糖尿病,年龄和性别进行调整;对长期酒精消费的变化进行了校正.
主要成果:
- 每周100克或更低的最低死亡风险.
- 增加的酒精消耗与中风,冠状动脉疾病 (不包括心肌梗塞),心力衰竭,高血压疾病和大动脉动脉瘤的风险增加有线相关.
- 较高的酒精摄入量 (> 100 g/周) 与预期寿命的缩短有关,而较高的摄入量则导致更大的寿命缩短.
结论:
- 对于目前的饮酒者来说,所有原因死亡风险最低的门约为100克/周.
- 对于心脏病亚型 (心肌梗塞除外) 没有明确的风险值,低于此,较低的酒精消耗不再降低风险.
- 目前的发现支持比大多数现有国家准则低的酒精消费限制.
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