超越宿主防御:免疫系统在复杂组织生理学的新兴功能
Lucille C Rankin1, David Artis1
1Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, and Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Cell
|April 21, 2018
概括
免疫系统不仅仅是对抗病原体. 它还能感知来自神经系统和饮食的信号, 调节全身功能并维持平衡.
科学领域:
- 免疫学
- 神经科学
- 代谢研究
背景情况:
- 免疫系统对于区分自我与非自我以及对抗病原体和瘤至关重要.
- 进步有详细的分子和细胞网络用于宿主防御和病原体驱逐.
- 新出现的证据突出显示免疫细胞感知到病原体以外的多种信号.
研究的目的:
- 提出免疫系统与其他器官系统相互作用的综合观点.
- 探索免疫系统如何感知和响应来自组织和环境的信号.
- 了解免疫系统在维持组织和全身平衡中的作用.
主要方法:
- 这篇评论综合了目前关于免疫系统信号的研究.
- 它整合了免疫学,神经科学和代谢研究的发现.
- 重点是器官间的沟通和平静调节.
主要成果:
- 免疫细胞感知来自神经系统和饮食的信号.
- 这些相互作用影响了新陈代谢和发热等生理过程.
- 免疫系统积极参与调节神经系统功能和组织修复.
结论:
- 免疫系统在感知和整合各种信号方面起着至关重要的作用.
- 免疫系统与其他器官系统的交叉通话对于平衡至关重要.
- 一个全面的理解需要将免疫系统视为全身生理学的中心调节器.
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