潜水的生理和遗传适应性
Melissa A Ilardo1, Ida Moltke2, Thorfinn S Korneliussen3
1Centre for GeoGenetics, University of Copenhagen, Copenhagen 1350, Denmark.
Cell
|April 21, 2018
概括
巴人以息潜水而闻名, 呈现低氧耐受性的遗传适应. 自然选择增加了脏大小并影响了潜水反射,
科学领域:
- 人类生理学
- 遗传学
- 进化生物学
背景情况:
- 人类的低氧耐受性在医学上具有重要意义,但主要在高海拔群体中进行研究.
- 像巴人一样, 潜水群体是研究适应低氧条件的未经探索的系统.
- 这种特殊的息能力表明,
研究的目的:
- 为了研究巴人非凡的呼吸能力的遗传基础.
- 通过对潜水群体的研究,探索人类对低氧耐受性的新适应.
主要方法:
- 对巴人进行比较基因组研究.
- 对基因变异及其与低氧耐受性相关的生理特征的分析.
主要成果:
- 在PDE10A基因上存在自然选择的证据,导致Bajau的脏大小增加.
- 一个更大的脏提供了一个更大的储存氧气红细胞.
- 在BDKRB2中发现强烈的巴特异性选择, 这是一种影响人类潜水反射的基因.
结论:
- 巴人表现出低氧耐受性的遗传适应性, 包括增加的脏大小和修改的潜水反射.
- 这些发现突出了巴人作为研究人类适应低氧环境的有价值模型.
- 这项研究为了解在具有挑战性的生理条件下生存的遗传机制开辟了新的途径.
相关概念视频
Effect of Sea Water on Concrete
1.1K
Concrete exposed to seawater can undergo degradation like the dissolution of ettringite and gypsum, increasing the material's porosity and decreasing its strength. In contrast, the crystallization of salts within the concrete's pores can cause expansion, particularly above the waterline where evaporation occurs. Nonetheless, this expansion only happens when seawater, enabled by the concrete's permeability, manages to infiltrate the structure.
Concrete in areas between tide marks,...
Concrete in areas between tide marks,...
1.1K
Genetics of Speciation
21.9K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.9K
What is Population Genetics?
65.0K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K
What is Genetic Engineering?
80.4K
Overview
80.4K
Physiological Barriers
5.3K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.3K
Animal Mitochondrial Genetics
9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K


