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Updated: Feb 11, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Published on: December 28, 2017

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一个整合的全基因组CRISPRa方法来功能化lncRNAs在药物耐药性

Assaf C Bester1, Jonathan D Lee1, Alejandro Chavez2

  • 1Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.

Cell
|April 21, 2018
PubMed
概括

这项研究引入了一个新的CRISPR查平台 (DICaS),用于发现影响癌症药物耐药性的基因. 它确定了新的细胞周期,生存和信号基因,包括GAS6-AS2 lncRNA,这有助于AML的化疗耐药性.

关键词:
洗钱问题在AXL/GAS6关于CRISPR的研究在CRISPRa中时间表癌症其他药物药物耐药性癌症 癌症在cRNA

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