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Updated: Feb 11, 2026

In vitro Methylation Assay to Study Protein Arginine Methylation
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通过其核导入受体和氨酸甲基化抑制FUS的相分离

Mario Hofweber1, Saskia Hutten2, Benjamin Bourgeois3

  • 1Biomedical Center (BMC), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany.

Cell
|April 21, 2018
PubMed
概括

在前性痴呆症 (FTD) 和肌性侧面硬化症 (ALS) 中,运输素和氨酸甲基化防止FUS蛋白聚合. 这些过程的中断促进FUS液相分离和压力颗粒的结合,从而导致神经退行.

关键词:
美国一个FTD卡里奥菲林-β2 (Kapβ2)运输 (TNPO1)氨酸甲基化在瘤中融化 (FUS)神经退行症核电的进口阶段分离压力颗粒

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