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相关概念视频

What is Population Genetics?01:25

What is Population Genetics?

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A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
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Conservation of Small Populations02:04

Conservation of Small Populations

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Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
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Genetics of Speciation02:16

Genetics of Speciation

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Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Population Growth00:57

Population Growth

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Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
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What are Populations and Communities?00:30

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Overview
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相关实验视频

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Molecular Evolution of the Tre Recombinase
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通过双重重组酶追踪非肌细胞群的遗传血统

Yan Li1, Lingjuan He1, Xiuzhen Huang1

  • 1The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, and Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, China (Yan Li, L.H., X.H., H.Z., S.Z., W.P., X.T., Yi Li, Q.L., W.Y., L.Z., X.L., K.L., J.T., H.Z., B.Z.).

Circulation
|April 28, 2018
PubMed
概括
此摘要是机器生成的。

新的研究表明,非心肌细胞可以在胚胎心脏中变成新的心肌细胞, 这一发现挑战了成人心脏干细胞用于心脏再生的概念.

关键词:
细胞系心肌梗塞心肌复血管化肌细胞,心脏复合物干细胞

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科学领域:

  • 心血管生物学
  • 干细胞研究
  • 复原医学

背景情况:

  • 成年哺乳动物心脏中用于心肌细胞再生的心脏干细胞的存在仍然是一个争论的话题.
  • 之前的研究报告了由各种标记物 (Sca1+,Bmi1+,Isl1+,Abc2+) 识别的或缺乏特定标记物的心脏干细胞种群.
  • 目前尚不清楚未识别的心脏干细胞是否能够在成年人心脏中产生新的心肌细胞.

研究的目的:

  • 研究非肌细胞在不依赖特定干细胞标志物的情况下在成年人心脏中产生新肌细胞的潜力.
  • 在体内追踪细胞系,以确定胚胎发育,成年人平衡和心肌梗塞后的新心肌细胞的起源.

主要方法:

  • 使用双重重组的新型无标记基因谱系系统的开发.
  • 应用该系统来追踪胚胎和成人心脏以及骨肌肉中的非肌细胞群作为对照.
  • 在各种生理和病理条件下从非肌细胞产生新型心肌细胞的评估.

主要成果:

  • 宿命映射数据显示,新的心肌细胞来自胚胎心脏中的非心肌细胞.
  • 没有证据表明成人心脏在恒常状态或心肌梗塞后转化为非肌细胞.
  • 血统追踪系统成功地检测到骨肌中的非肌细胞产生新的肌细胞,作为积极对照.

结论:

  • 这项研究提供了体内遗传证据,表明非肌细胞转化发生在胚胎心脏中,但未发生在成人心脏中.
  • 这些发现挑战了成年哺乳动物心脏再生的干细胞群的肌体潜力.
  • 在其他器官系统中发现用于组织修复的内源干细胞的新遗传策略.