Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Embryonic Stem Cells00:58

Embryonic Stem Cells

32.6K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.6K
Embryonic Stem Cells00:57

Embryonic Stem Cells

5.2K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.2K
Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
Antibody Structure01:10

Antibody Structure

65.7K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.7K
Structural Isomerism02:34

Structural Isomerism

21.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Replication-stress-induced chromatin loops protect fork stability.

Nature·2026
Same author

Functional annotation of non-coding variants identifies a novel enhancer with activity in neural crest cell-derived lineages.

Research square·2026
Same author

DNA repair drives cisplatin-induced neuronal death.

Cell·2026
Same author

Single-cell co-mapping reveals relationship between chromatin state and gene expression in early zebrafish development.

eLife·2026
Same author

Author Correction: Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance.

Nature methods·2026
Same author

CFAP20 salvages arrested RNAPII from the path of co-directional replisomes.

Nature·2026

相关实验视频

Updated: Feb 11, 2026

Derivation of Mouse Trophoblast Stem Cells from Blastocysts
10:19

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Published on: June 8, 2010

18.8K

仅从干细胞生成的类似胚胎细胞的结构

Nicolas C Rivron1,2, Javier Frias-Aldeguer3,4, Erik J Vrij3

  • 1MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands. n.rivron@hubrecht.eu.

Nature
|May 4, 2018
PubMed
概括
此摘要是机器生成的。

早期的哺乳动物胚胎发育涉及到皮和胚胎细胞. 在体外,这些细胞形成了叶囊体,模仿叶囊体,并揭示了对 trofhectoderm 发育和植入至关重要的胚胎诱导.

更多相关视频

Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

23.7K
Author Spotlight: Simple and Efficient Neural Retina Organoid Production for Disease Modeling
05:03

Author Spotlight: Simple and Efficient Neural Retina Organoid Production for Disease Modeling

Published on: December 22, 2023

2.0K

相关实验视频

Last Updated: Feb 11, 2026

Derivation of Mouse Trophoblast Stem Cells from Blastocysts
10:19

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Published on: June 8, 2010

18.8K
Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

23.7K
Author Spotlight: Simple and Efficient Neural Retina Organoid Production for Disease Modeling
05:03

Author Spotlight: Simple and Efficient Neural Retina Organoid Production for Disease Modeling

Published on: December 22, 2023

2.0K

科学领域:

  • 发育生物学
  • 干细胞生物学
  • 哺乳动物胚胎生成

背景情况:

  • 胚胎囊,一个早期的哺乳动物胚胎,包括体和胚胎细胞,形成所有的胚胎和胚胎外组织.
  • 多细胞干细胞和胚胎干细胞是这些部分的体外类似物.
  • 了解细胞之间的相互作用是早期胚胎发育的关键.

研究的目的:

  • 在体外研究热囊细胞和胚胎干细胞之间的合作相互作用.
  • 描述由这些合作细胞所形成的结构,
  • 阐明调节体发育的胚胎诱导信号.

主要方法:

  • 从小鼠胚芽细胞衍生出热囊细胞和胚胎干细胞系.
  • 这些细胞类型的共同培养形成了体.
  • 单细胞转录组学和细胞区的遗传/物理解.
  • 在体内植入和决定化试验.

主要成果:

  • 热囊细胞和胚胎干细胞合作形成布拉斯托,类似于小鼠囊.
  • 胚胎细胞提供诱导信号,通过BMP4/Nodal-KLF6轴驱动肌体发育,包括增殖和形态发生.
  • 布拉斯托体显示出广泛的胚胎诱导,这对于 trofhectoderm 功能,植入和决定化至关重要.

结论:

  • 胚胎诱导对于建立功能性肌体至关重要.
  • 新生胚胎积极支持肌体的发育和植入.
  • 布拉斯托体作为研究早期胚胎细胞相互作用和信号通路的模型.