一个中线的胸膜电路决定了对视觉威胁的反应
Lindsey D Salay1, Nao Ishiko1, Andrew D Huberman2,3,4,5
1Department of Neurobiology, Stanford University School of Medicine, Palo Alto, CA, USA.
Nature
|May 4, 2018
概括
腹部中线丘脑 (vMT) 通过将视觉信息发送到不同大脑区域来控制威胁反应. 这会影响老鼠是否结或面对威胁,影响适应性决策.
科学领域:
- 神经科学
- 行为神经科学
- 如何做出决定
背景情况:
- 内部状态与视觉威胁感知的整合以引导适应性行为仍然不清楚.
- 小鼠表现出不同的行为策略,如结或寻找避难所,以应对视觉威胁.
研究的目的:
- 确定内在状态和视觉威胁感知的基础的神经回路.
- 阐明腹部中线丘脑 (vMT) 在控制对威胁的行为反应中的作用.
主要方法:
- 在小鼠中研究了特定的vMT核的功能,包括状核 (Xi) 和重聚核 (Re).
- 使用投影特定路径跟踪和激活来分析神经路径及其行为输出.
主要成果:
- 核向底侧桃体投射,促进结 (减少的威胁反应).
- Re核向中部前额叶皮质 (Re→mPFC) 发射,驱动像尾巴一样的对抗反应 (增强性).
- 激活Re→mPFC通路可以增强自主性兴奋,并有所回报.
结论:
- 它作为一个关键的枢纽, 将内部状态转化为对立的行为反应.
- 这些发现有助于了解因兴奋障碍和决策障碍而导致的疾病,
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