Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Trigonometric Identities II01:28

Trigonometric Identities II

433
Double-angle and half-angle trigonometric identities are derived from the fundamental sum and difference formulas and serve as essential tools for simplifying expressions, solving equations, and evaluating integrals. These identities reduce the complexity of trigonometric functions by relating functions of a multiple or fractional angle to functions of a single angle. Their applications extend across mathematics, physics, and engineering, particularly in Fourier analysis, wave mechanics, and...
433
Personal Identity01:25

Personal Identity

460
Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
460
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
Social Identity01:29

Social Identity

358
Social identity constitutes a significant aspect of an individual’s self-concept, shaped by membership in various social groups, including gender, nationality, ethnicity, sexual orientation, and political affiliation. Individuals associate specific traits with particular social groups, leading to internalization of these traits. For example, musicians are often perceived as creative, while women are frequently associated with nurturing tendencies. Once individuals identify with a...
358
Trigonometric Identities I01:27

Trigonometric Identities I

252
Trigonometric identities are equations that relate trigonometric functions and hold for all angles within their domains. A fundamental identity among these is the Pythagorean identity, which arises directly from the geometry of the unit circle. For any angle θ, a point on the unit circle has coordinates (cos⁡ θ, sin ⁡θ), and since the radius of the circle is one, the Pythagorean Theorem gives:This identity serves as the basis for deriving additional identities.
252

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Selphi, a tool for improving genotype imputation accuracy.

Scientific reports·2026
Same author

Letter regarding "Testosterone and abdominal aortic aneurysm".

Journal of vascular surgery·2026
Same author

Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue.

bioRxiv : the preprint server for biology·2026
Same author

Echocardiographically occult nonbacterial thrombotic endocarditis with tumor cell-containing valvular vegetations in metastatic breast cancer.

Cardio-oncology (London, England)·2026
Same author

Characterisation of PAHs in Outdoor Air Pollution at Schools in a Medium-Sized Town, Hungary.

Toxics·2026
Same author

Conserved Kir channel mechanisms governing intrinsic excitability in human and rodent parvalbumin neurons.

Communications biology·2026

相关实验视频

Updated: Feb 10, 2026

Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes
07:25

Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes

Published on: July 7, 2022

3.3K

神经元身份的多种重编程代码

Rachel Tsunemoto1,2, Sohyon Lee1, Attila Szűcs3,4

  • 1Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA.

Nature
|May 11, 2018
PubMed
概括
此摘要是机器生成的。

研究人员确定了76对转录因子,这些因子将小鼠纤维细胞重新编程成诱导的神经元 (iN细胞). 这项研究定义了一个核心的神经元特征,并揭示了NN细胞多样性,扩大了神经工程的工具.

更多相关视频

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
07:53

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

Published on: January 1, 2018

8.2K
Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
06:32

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

Published on: June 5, 2017

7.6K

相关实验视频

Last Updated: Feb 10, 2026

Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes
07:25

Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes

Published on: July 7, 2022

3.3K
Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
07:53

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

Published on: January 1, 2018

8.2K
Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
06:32

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

Published on: June 5, 2017

7.6K

科学领域:

  • 神经科学
  • 发育生物学
  • 分子生物学

背景情况:

  • 神经元的身份和多样性源于发育过程中的复杂的转录程序.
  • 转录因子的短暂表达可以将非神经细胞重新编程为神经元类型.
  • 重编程因子与内生神经网络之间的相互作用尚不清楚.

研究的目的:

  • 确定诱导纤维细胞中神经元分化的转录因子组合.
  • 定义诱导神经元 (iN细胞) 的核心转录特征.
  • 探索由不同因素组合产生的IN细胞的多样性及其功能影响.

主要方法:

  • 选598个转录因子对进行重编程.
  • 将IN细胞与内源性神经元进行转录组分析.
  • 细胞转录模式与药理反应的相关性.

主要成果:

  • 确定了76对能够诱导小鼠纤维细胞中神经元特征的转录因子.
  • 定义了多种IN细胞共享的核心细胞自主转录特征.
  • 证明不同的转录因子组合产生具有独特的转录特征和可预测的功能性质的IN细胞.

结论:

  • 这项研究扩展了产生具有特定特征的诱导神经元的工具箱.
  • 这些发现描绘了神经元身份和多样性的细胞自主特征.
  • 这些结果有助于为研究和潜在的治疗应用设计NN细胞.