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Updated: Feb 10, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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通过分离的NAD+生物合成对转录的代谢调节

Keun Woo Ryu1,2,3, Tulip Nandu1,2, Jiyeon Kim4

  • 1Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|May 12, 2018
PubMed
概括

尼古丁胺氨基二核酸 (NAD+) 合成的分离整合了葡萄糖代谢和脂肪细胞的分化. 通过NMNAT-2的细胞质NAD+合成降低了核NAD+,抑制了PARP-1并驱动了脂肪生成.

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