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质子转移水凝:多功能性和应用

JiHyeon Hwang¹, Dong G Lee¹, Hyunki Yeo¹

¹Department of Chemical and Biological Engineering , Korea University , Seoul , 02841 , South Korea.

Journal of the American Chemical Society

|May 17, 2018

概括

这项研究提出了一种多功能氧化物聚合,用于制造可调节的水凝. 这些可适应的水凝具有生物相容性,并可用于抗菌性质,展示其广泛的应用潜力.

科学领域:

聚合物化学
材料科学
生物材料工程

背景情况:

水凝是具有多样性的重要生物材料.
开发可适应和可调节的水凝合成方法对于先进的材料设计至关重要.
现有的方法在聚合条件,前体或合成后的修改中可能缺乏多功能性.

研究的目的:

证明硫醇和环氧化物的质子转移聚合是一种多用途的水凝合成方法.
通过前体选择和聚合条件来探索水凝的可调性.
调查功能化潜力和由此产生的材料特性,包括抗菌性质.

主要方法:

在醇和环氧功能组之间利用质子转移聚合.
探索各种聚合催化剂 (有机/无机) 和介质 (水,缓冲剂,有机溶剂).
研究的不同凝触发因素:环境条件,37°C和光 (光化学).
采用纳米印记光刻技术制作图案片.
在凝后功能化乙烯基组以创建离子结构.

主要成果:

在各种条件下通过氧化物聚合实现了可适应的水凝合成.
通过选择前体和条件,证明了吸水,机械和生物降解性能.
通过环境和光化学方法成功生产独立的图案厚薄膜.
通过化后的功能化来制造抗菌水凝,以硫为基础的阴离子结构.
在原始凝中观察到生物相容性和非粘合性,促进癌细胞集群的形成.

结论:

硫醇和环氧化物的质子转移聚合是一种高度适应和实用性的水凝合成方法.
该方法可以精确控制水凝的特性,并引入特定的功能,如抗菌活性.
由此产生的生物相容和可调节的水凝有望用于各种生物医学应用,包括组织工程和药物输送.

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