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防止编辑缺陷tRNA合成酶导致的神经元损失

My-Nuong Vo1, Markus Terrey2,3,4,5, Jeong Woong Lee5,6

  • 1The Skaggs Institute for Chemical Biology, Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA, USA.

Nature
|May 18, 2018
PubMed
概括

安基林重复域16 (ANKRD16) 蛋白通过纠正阿拉尼尔tRNA合成酶 (AlaRS) 的错误来防止神经退行. 这一发现揭示了防止严重病理编辑缺陷的新机制.

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