对微生物代谢物的微细胞控制
Veit Rothhammer1, Davis M Borucki1, Emily C Tjon1
1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nature
|May 18, 2018
概括
通过TGFα和VEGF-B调节中枢神经系统 (CNS) 中的星球细胞活动. 饮食中的微生物及其代谢物可以抑制中枢神经系统的炎症,
科学领域:
- 神经科学
- 免疫学
- 微生物学
背景情况:
- 微细胞和星球细胞是中枢神经系统 (CNS) 炎症和神经退化中的关键细胞.
- 微质调节星球细胞的促炎和神经毒性活动的机制尚未完全理解.
研究的目的:
- 研究微质衍生因子在神经炎症期间调节星球细胞活动中的作用.
- 探索微生物代谢物对微细胞相互作用和中枢神经系统炎症的影响.
主要方法:
- 使用多发性硬化症的自免疫脑髓炎 (EAE) 试验小鼠模型.
- 分析了TGFα和VEGF-B在微质细胞和星球细胞中的表达和功能.
- 研究了饮食中酸代谢物和酸受体通路的作用.
主要成果:
- 微细胞衍生TGFα通过ErbB1信号来限制致病性天体细胞活动和EAE严重性.
- 微质VEGF-B通过激活星球细胞中的FLT-1信号来加剧EAE.
- 在CD14+细胞中的TGFα和VEGF- B表达与多发性硬化病变阶段相关.
- 饮食中的酸代谢物调节微质激活和天体细胞转录程序,通过酸受体抑制中枢神经系统炎症.
结论:
- 确定TGFα和VEGF-B是中枢神经系统中微质细胞控制的关键调节剂.
- 发现微生物代谢物通过调节微质和星球细胞功能来抑制神经炎症.
- 这些发现表明多发性硬化和其他神经系统疾病的潜在治疗策略.
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