体通过瞬间的动作选择来组织3D行为
Jeffrey E Markowitz1, Winthrop F Gillis2, Celia C Beron1
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Cell
|May 22, 2018
概括
研究人员发现,小鼠的背侧条纹体 (DLS) 使用不同的神经通路动态来编码和组装顺序行为. 这个大脑区域对于从基本组件构建复杂的动作至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 计算神经科学是一种神经科学.
背景情况:
- 自然主义行为由连续的行动模块组成.
- 背侧条纹体 (DLS) 参与了行动选择,但其在无约束动物中排序复杂行为中的作用尚不清楚.
研究的目的:
- 为了研究底层的神经机制组成的连续行为在DLS.
- 了解DLS中神经活动如何编码行为元素及其时间顺序.
主要方法:
- 在自发行为期间,在小鼠的DLS的直接和间接途径中记录了批量和细胞神经活动.
- 利用3D运动跟踪来分析次秒的行为动机.
- 进行了DLS损伤,以评估对序列组装的影响.
主要成果:
- DLS神经元编码3D行为动机的身份和顺序.
- 直接和间接路径之间的快速时间尺度的对应关系促进了这种编码.
- DLS病变损害了在探索性和气味唤起的行为过程中行为序列的组装.
结论:
- DLS在其直接和间接路径中使用互补动态来创建基本3D姿势动态的神经代码.
- DLS在从模块化组件中构建有意义的行为序列方面发挥着关键作用.
- 这些发现表明神经回路如何随着时间的推移塑造行动的模型.
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