高发射自组装的BODIPY-白金超分子三角形
Jiong Zhou1,2, Yuzhen Zhang2, Guocan Yu1,3
1State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance and Novel Materials, Department of Chemistry , Zhejiang University , Hangzhou 310027 , P. R. China.
Journal of the American Chemical Society
|May 23, 2018
概括
两种新的 (II) 超分子协调复合物 (SCC) 与BODIPY连接物显示出强大的抗癌活性. 这些治疗药物结合化疗和光动力疗法 (PDT) 以提高疗效,甚至对抗药物耐药的癌细胞.
科学领域:
- 超分子化学
- 材料科学
- 化学生物学
背景情况:
- 超分子协调复合物 (SCC) 在化学和生物应用中具有价值.
- 基于的化合物被广泛研究其治疗潜力.
- BODIPY染料具有出色的光和光动力学特性.
研究的目的:
- 用BODIPY连接物合成和表征新的 (II) 超分子三角形.
- 评估它们的抗癌作用和治疗潜力.
- 探索它们对抗抗药性癌细胞的有效性.
主要方法:
- 和BODIPY连接物的协调驱动自组合.
- 对HeLa和A2780cis细胞系进行体外抗癌活性测定.
- 用于细胞内可视化的聚焦显微镜.
- 计算组合指数以评估协同效应.
主要成果:
- 两种高发射 (II) 超分子三角形 (1和2) 已成功合成.
- 这两种复合物对HeLa细胞具有显著的抗癌活性.
- 这些复合物使细胞内可视化,并在化疗和光动力疗法 (PDT) 中表现出协同作用.
- 对抗抗的A2780cis细胞观察到更高的疗效,突出显示了克服耐药性的潜力.
结论:
- 开发的 (II) - BODIPY SCCs是有效的治疗药物, 结合化疗和PDT.
- 这些复合物有望克服抗药性.
- 模块化设计允许独立调整组件以优化治疗活动.
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