Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Switching of BJT01:22

Switching of BJT

873
Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are...
873
What is Natural Selection?01:32

What is Natural Selection?

129.7K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.7K
Antibiotic Selection00:57

Antibiotic Selection

60.1K
Overview
60.1K
Types of Selection01:46

Types of Selection

45.3K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
45.3K
Persuasion Strategies01:52

Persuasion Strategies

43.5K
Researchers have tested many persuasion strategies, including the foot-in-the door and the door-in-the-face techniques, in a variety of contexts. Ultimately, the principles are effective in selling products and changing people’s attitude, ideas, and behaviors (Cialdini & Goldstein, 2004).
43.5K
Frequency-dependent Selection01:21

Frequency-dependent Selection

24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Phosphonium Ions as Activating Groups for the Selective Alkylation of Pyridines and Polyazines.

Journal of the American Chemical Society·2026
Same author

Potassium Bisulfite's Role in Developing a Robust Platform for Enantioenriched <i>N</i>-Alkylpyridinium Salts as Piperidine Precursors.

Journal of the American Chemical Society·2026
Same author

Stable Isotope Labeling of Pyrimidines Using a Deconstruction-Reconstruction Strategy.

Journal of the American Chemical Society·2025
Same author

A Broadly Applicable Strategy to Aminate Azines Enabled by Electronically Tuned Phosphine Reagents.

Angewandte Chemie (International ed. in English)·2025
Same author

3-Selective Pyridine Fluorination via Zincke Imine Intermediates.

Journal of the American Chemical Society·2025
Same author

A deconstruction-reconstruction strategy for pyrimidine diversification.

Nature·2024

相关实验视频

Updated: Feb 10, 2026

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.7K

选择性切换策略以使多氨酸具有功能

Ryan D Dolewski1, Patrick J Fricke1, Andrew McNally1

  • 1Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , United States.

Journal of the American Chemical Society
|May 25, 2018
PubMed
概括

研究人员开发了一种新方法,在聚结构中选择性地功能化C-H键,使有价值的药物衍生物更容易合成. 这种选择性离子装置为药物化学应用提供了多功能处理器.

科学领域:

  • 有机化学
  • 医学化学
  • 合成化学

背景情况:

  • 在药物碎片和治疗化合物中常见的是含有多个氨酸和氨酸环的多氨酸结构.
  • 在这些复杂分子中开发C-H键转换的选择性反应对于有效合成衍生物至关重要.

研究的目的:

  • 介绍一种用于选择性安装离子功能手柄在聚结构上的新方法.
  • 描述控制位置选择性的因素,并展示切换选择性的机械驱动方法.

主要方法:

  • 使用离子装置进行选择性C-H键功能化.
  • 调查聚系统中控制位点选择性的固有因素.
  • 机械研究使功能化站点可预测的切换.

主要成果:

  • 用离子 (C-+PPh3) 作为一个多功能手柄的成功和选择性安装.
  • 确定控制反应部位选择性的关键因素.
  • 对可预测的选择性切换的机械驱动方法的演示.

结论:

  • 开发的方法为药物化学家提供了一种简单而有吸引力的方法来获取有价值的聚衍生物.

更多相关视频

Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection
08:37

Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection

Published on: December 10, 2015

19.9K
Measuring the Switch Cost of Smartphone Use While Walking
07:00

Measuring the Switch Cost of Smartphone Use While Walking

Published on: April 30, 2020

2.3K

相关实验视频

Last Updated: Feb 10, 2026

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.7K
Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection
08:37

Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection

Published on: December 10, 2015

19.9K
Measuring the Switch Cost of Smartphone Use While Walking
07:00

Measuring the Switch Cost of Smartphone Use While Walking

Published on: April 30, 2020

2.3K
  • 简单的方案和随时可用的试剂使这种技术更容易应用于复杂的类似药物的分子.