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结肠镜检查结果与长期结肠直肠癌发生率的关联
Benjamin Click1, Paul F Pinsky2, Tom Hickey3
1Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
JAMA
|May 26, 2018
概括
在结肠镜检查中发现的晚期腺瘤患者患结肠直肠癌 (CRC) 和CRC死亡的风险显著增加. 非晚期腺瘤似乎不会增加CRC的风险.
科学领域:
- 胃肠病学
- 癌症学
- 预防医学
背景情况:
- 腺多需要进行结肠镜检查以预防结肠直肠癌 (CRC).
- 结肠镜检查结果与随后的CRC发病率之间的长期关联尚不清楚.
研究的目的:
- 根据结肠镜检查中的腺瘤发现,比较长期结肠直肠癌 (CRC) 的发生率.
主要方法:
- 一项多中心前性队列研究,涉及15935名前列腺,肺部,结肠直肠和卵巢 (PLCO) 癌症试验的参与者.
- 参与者经过结肠镜检查后,得到了灵活的细分镜检查 (FSG) 结果,结果被分类为晚期腺瘤,未晚期腺瘤或没有腺瘤.
- 对CRC发病率和死亡率的随访时间均为12. 9年.
主要成果:
- 与没有腺瘤的参与者相比,患有晚期腺瘤的CRC发病率显著更高 (每10,000人/年为20. 0).
- 晚期腺瘤与CRC风险增加2. 7倍和CRC死亡风险增加2. 6倍有关.
- 在非晚期腺瘤和没有腺瘤的参与者之间没有观察到CRC风险或死亡率的显著差异.
结论:
- 在结肠镜检查中发现的晚期腺瘤与结肠直肠癌和结肠直肠癌死亡率的长期风险显著增加有关.
- 没有晚期腺瘤的存在可能与发展CRC的风险增加无关.
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