星球细胞激活产生了新的神经元增强和记忆增强
Adar Adamsky1, Adi Kol1, Tirzah Kreisel1
1Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Cell
|May 29, 2018
概括
星细胞激活足以诱导突触可塑性并增强记忆回忆. 这一发现表明星体细胞在认知功能中起着关键作用,并可能为增强记忆力的治疗提供新的途径.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
背景情况:
- 众所周知,星体细胞是一种质细胞,对神经元活动做出反应.
- 已经证明,星细胞活动对于突触可塑性和记忆形成是必要的.
研究的目的:
- 为了调查是否有足够的天体细胞活动来诱导突触强化和增强记忆.
- 探索星体细胞在认知过程中的作用.
主要方法:
- 使用设计药物的CA1天体细胞中Gq结合受体hM3Dq的化学遗传激活.
- 天体细胞的光遗传激活.
- 在体内实验测量记忆分配和回忆.
- 直接的神经元激活用于比较.
主要成果:
- 天体细胞激活足以诱导海马体中依赖NMDA的长期强化.
- 在体内,星细胞激活增强了记忆分配,特别是在与学习相结合时.
- 在学习过程中,化学遗传和光遗传的天体细胞激活都改善了随后的记忆回忆.
- 直接增加神经元活动会影响记忆.
结论:
- 星细胞活动不仅是必要的,而且足以诱导突触可塑性和增强记忆力.
- 向星球细胞可能为认知增强提供了一种新的治疗策略.
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