作者纠正:B淋巴细胞转录因子的代谢守门员功能
Lai N Chan1,2, Zhengshan Chen1,2, Daniel Braas3
1Department of Systems Biology, Beckman Research Institute and City of Hope National Medical Center, Pasadena, California, 91016, USA.
Nature
|June 1, 2018
概括
在一封详细介绍白血病细胞CRISPR-Cas9基因缺失的信中对一个数字进行了修正. 错误涉及错误的数据,但不会影响研究的结论.
科学领域:
- 遗传学和基因组学
- 癌症学
- 细胞生物学
背景情况:
- CRISPR-Cas9基因编辑是研究基因功能的一个强大工具.
- 乙系白血病是一种严重的血液恶性瘤.
- NR3C1,TXNIP和CNR2是细胞过程和疾病感兴趣的基因.
研究的目的:
- 研究患者衍生的B系白血病细胞中删除NR3C1,TXNIP和CNR2基因的影响.
- 为科学可重复性提供透明和准确的数据表示.
主要方法:
- 通过CRISPR-Cas9进行基因删除.
- 来自患者的B系白血病细胞分析.
- 为提高透明度,对数字进行纠正并提供补充数据.
主要成果:
- 在图3c的数据绘制中发现了一个错误,NR3C1数据被无意中替换为TXNIP数据.
- 该数字已在网上进行了校正,并提供了原来的数字作为补充信息.
- 发现的错误并没有改变研究的原始结论.
结论:
- 这封信的科学结论仍然有效,尽管图3c中存在数据绘图错误.
- 通过更正的数字和补充的来源数据提供了更好的数据透明度.
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