在鱼和滑板上的电感受分子调整
Nicholas W Bellono1,2, Duncan B Leitch3, David Julius4
1Department of Physiology, University of California, San Francisco, San Francisco, CA, USA. nbellono@harvard.edu.
Nature
|June 1, 2018
概括
鱼和滑板动物在他们的电感应细胞中使用不同的离子通道. 这些分子差异调整了它们的感官感知,使鱼能够进行广泛的信号检测,滑板用于选择性频率检测.
科学领域:
- 海洋生物学 海洋生物学
- 神经科学是一个神经科学.
- 感官生理学 感官生理学
背景情况:
- 古代的软骨脊椎动物,如鱼和滑冰者,拥有电感器官来检测电场.
- 这种感官模式对于诸如捕食 (鱼) 和同类沟通 (滑板) 等行为至关重要.
研究的目的:
- 调查电感官细胞中明显的生理特性是否有助于鱼和滑冰中的行为相关的感官调整.
- 了解弹性枝状动物感官适应的分子和生物物理基础.
主要方法:
- 对来自鱼和滑板动物的电感官细胞的分析.
- 研究电压调节的和通道表达和功能.
- 电生理学记录以表征细胞活动和突触释放.
主要成果:
- 鱼和滑冰者都使用类似的低值电压通道来启动细胞活动.
- 鱼表达特殊的通道,使大,重复的尖峰几乎最大的囊泡释放.
- 滑板使用激活通道进行小,可调节的振荡和刺激依赖的释放.
结论:
- 明显的通道表达导致鱼和滑板电感官系统中细胞活动的差异调节.
- 这些适应支持鱼的放大,不分青红白的信号检测,而滑板车的选择性频率检测.
- 感官系统在分子和生物物理上适应动物的生态利基和行为要求.
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