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哺乳动物味道系统中的价值和身份编码
Li Wang1,2,3, Sarah Gillis-Smith1,2,3, Yueqing Peng1,2,3
1Howard Hughes Medical Institute, Columbia University, New York, NY, USA.
Nature
|June 1, 2018
概括
它们使用不同的大脑路径来识别口味并赋予它们正面或负面的价值. 沉默杏仁核会影响口味驱动的行为,
科学领域:
- 神经科学
- 感官系统
- 味觉感知
背景情况:
- 味道系统可以识别味道,从而识别基本的味道品质.
- 味觉价值 (食欲或厌恶) 决定了快乐的价值,并指导了行为.
研究的目的:
- 在小鼠中研究甜味和苦味是如何被赋予价值与身份的.
- 探索底层的神经基质的味道价值和识别.
主要方法:
- 从甜味和苦味反应的皮质神经元到杏仁体的检查.
- 操纵桃体的选择性味道输入.
- 沉默桃体中的神经元来评估行为反应.
主要成果:
- 对于甜味和苦味反应的皮质神经元向不同的杏仁体区域投射, 分离食欲和厌恶信号.
- 桃体操纵改变了味觉刺激的价值, 包括逆转快乐的价值.
- 桃体沉默消除了基于价值的行为,
结论:
- 桃体在赋予味觉刺激的价值方面起着至关重要的作用.
- 存在不同的神经基质来进行味道识别和价值赋值.
- 这些发现解释了天生的吸引力和厌恶性品味行为.
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