波长选择光响应的DASA功能化聚合物纳米反应器
Omar Rifaie-Graham1, Sebastian Ulrich1,2, Nikolas F B Galensowske1
1Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
Journal of the American Chemical Society
|June 2, 2018
概括
研究人员使用捐赠者-接受者斯坦豪斯附加物 (DASA) 开发了对光敏感的聚合物纳米反应器. 这些纳米反应器可以在可见光下打开,并在黑暗中恢复到无活跃状态,从而实现可控化学反应.
科学领域:
- 材料科学
- 聚合物化学
- 纳米技术
背景情况:
- 光受体细胞利用短暂的光激活进行生化过程.
- 人工纳米系统试图模仿对光的反应.
研究的目的:
- 用可见光进行切换的聚合物纳米反应器.
- 在黑暗中实现快速自我回归到无活动状态.
- 为了实现光控制的催化和有效载荷释放.
主要方法:
- 通过RAFT聚合合成两块共聚物.
- 使用Meldrum的基于酸或基于pyrazolone的DASAs进行功能化.
- 自组装成聚合体囊泡以控制透性.
主要成果:
- 聚合物呈现出光触发的有效载荷释放,在光移除时停止.
- 在纳米反应器中封装的酶仅在可见光照射下催化反应.
- 使用绿色和红色光敏感纳米反应器实现了波长选择性催化.
结论:
- 基于DASA的纳米反应器为光控制的膜透性提供了一个有希望的平台.
- 这些系统显示了在微流体和药物输送中按需切换反应的潜力.
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