双虹 (III) 复合体扩展氧气传感从低氧到高氧
Kenneth Yin Zhang1, Pengli Gao1, Guanglan Sun1
1Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) , Nanjing University of Posts & Telecommunications , 9 Wenyuan Road , Nanjing 210023 , P. R. China.
Journal of the American Chemical Society
|June 7, 2018
概括
研究人员开发了用于双光的新型 (III) 复合物,使低氧和高氧同时进行生物成像. 这一突破为生物应用广泛的氧气范围提供了前所未有的灵敏度.
科学领域:
- 化学 化学 化学
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 缺氧和高氧是影响生物组织的病理状况.
- 现有的发光氧探头缺乏对高氧的敏感性.
- 双模式光为更广泛的氧气传感提供了一个潜在的解决方案.
研究的目的:
- 为氧气感应开发具有双光的新型 (III) 复合物.
- 为了实现光特性对氧气反应的合理调整.
- 为了实现低氧和高氧的同时生物成像.
主要方法:
- (III) 复合物的合成和结构操纵.
- 研究涉及内部转换的双光机制.
- 对依赖氧气的光谱反应的表征.
- 氧气水平的体外和体外生物成像.
主要成果:
- 开发出从不同的激发状态表现出双光的 (III) 复合体.
- 实现了用于氧气传感的光谱谱的合理调整.
- 在不同氧度 (N2,空气,O2) 的情况下,裸眼可辨别的排放变化 (绿色,色,红色).
- 成功地应用了探头用于细胞内和体内氧气成像在低氧,正常和高氧范围.
结论:
- 这项研究介绍了第一个能够同时对低氧和高氧的生物成像的分子探测器.
- 开发的 (III) 复合体为灵敏的氧气传感提供了一个多功能平台.
- 这项技术对理解和诊断与氧相关的病理有重大影响.
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