TCR转基因小鼠逐步发现独特的脂肪-Treg表现型
Chaoran Li1, Joanna R DiSpirito1, David Zemmour1
1Department of Microbiology and Immunobiology and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Cell
|June 12, 2018
概括
内脏脂肪组织 (VAT) 的调节T细胞具有独特的功能. 一个新的小鼠模型揭示了这些VAT Treg细胞如何发育和运作, 提供了有关炎症和代谢控制的见解.
科学领域:
- 免疫学
- 代谢研究
- 细胞生物学
背景情况:
- 内脏脂肪组织 (VAT) 含有具有明显表型的调节性T细胞.
- 这些VAT Treg细胞对于调节局部和全身炎症和代谢至关重要.
- 了解它们的起源和功能是治疗策略的关键.
研究的目的:
- 调查增值税Treg细胞的发展,依赖关系和活动.
- 阐明T细胞受体特异性在VAT Treg细胞功能中的作用.
- 在VAT Treg细胞中发现转录因子和受体的新功能.
主要方法:
- 产生具有富含VAT Tregs的T细胞受体转基因小鼠系.
- 对Treg细胞来源,依赖性和活动的分析.
- 研究转录因子 (Foxp3) 和受体 (互白素-33受体) 的作用.
主要成果:
- 确立了T细胞受体特异性在VAT Treg细胞发展中的关键作用.
- 在增值税Tregs中发现了转录因子Foxp3的新功能.
- 在VAT Treg功能中证明了interleukin-33受体的细胞内在作用.
- 详细介绍了增值税Treg细胞生成的两步过程:脏原始化和增值税多样化.
结论:
- VAT Treg细胞表型来自脏原始化和VAT微环境线索.
- 对于它们的功能来说,Treg细胞受体特异性和Foxp3和IL-33R等关键分子参与者至关重要.
- 阐明组织Treg生物学原理对于开发代谢和炎症疾病的向疗法至关重要.
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