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Updated: Feb 9, 2026

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome
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SMCHD1将染色体组合并协助在不活跃的X上形成超级结构

Chen-Yu Wang1, Teddy Jégu1, Hsueh-Ping Chu1

  • 1Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.

Cell
|June 12, 2018
PubMed
概括

含有1 (SMCHD1) 蛋白质的染色体结构维护链域重新配置非活跃的X染色体. SMCHD1通过减弱隐藏的Xi架构层来促进Xist的传播,从而创建一个没有隔间的结构.

关键词:
多复合物标签: SMCHD1一个TADX 染色体的不活化基因组RNA染色体形状隔间长非编码RNA核组织在拓上关联域

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