对素类型二类类化合物的一种嵌方法:素 (达维素) 的合成
Kevin G M Kou1, Jason J Pflueger1, Toshihiro Kiho1
1Department of Chemistry , University of California, Berkeley , Berkeley , California 94720 , United States.
Journal of the American Chemical Society
|June 12, 2018
概括
研究人员开发了一种复杂的类类化合物的新合成策略. 这种方法可以获得A环化化合物,扩大发现新天然和非天然产品的潜力.
科学领域:
- 有机化学
- 自然产品合成
- 医学化学
背景情况:
- 黑类天然产品是一种因其复杂的碳骨架而闻名的二类化物.
- 由于它们的结构复杂,
- 之前的合成方法在获取特定的结构图案方面存在局限性,例如A环化.
研究的目的:
- 开发一种新的高效合成策略,用于素类型的二类化物.
- 为了使A环化素衍生物的合成.
- 提供一个通用的平台, 让人们可以在这种类化合物家族中获取更广泛的天然和非天然产品.
主要方法:
- 使用网络分析来设计融合合成策略.
- 采用乙烯基化来构建一个化的6-7-6三环芯.
- 包含化学选择性缩和顺序性C-N键形成.
- 应用了还原性循环和光化学胺化,以构建嵌入式阿扎比基.
主要成果:
- 成功建立了合成复杂的二类化物的途径.
- 证明了在A环上引入氧化的能力.
- 构建了具有特色的融合式6-7-6三轮车和嵌入式azabicycle核心结构.
- 验证了包括化学和光化学反应在内的关键转化.
结论:
- 开发的合成策略有效地通过A环化来获取黑类化物.
- 这种方法提供了一个强大的工具,用于在化物家族的化学空间的探索.
- 这项战略有望发现新的生物活性化合物和类似物.
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