单壁碳纳米管通过乳液聚合涂层
Yukiko Nagai1, Yusuke Tsutsumi1, Naotoshi Nakashima2
1Department of Applied Chemistry, Graduate School of Engineering , Kyushu University , 744 Motooka , Nishi-ku, Fukuoka 819-0395 , Japan.
Journal of the American Chemical Society
|June 16, 2018
概括
我们开发了一种新的单壁碳纳米管 (SWNT) 混合材料用于向癌症治疗和成像. 这种生物相容的平台能够精确地输送治疗剂并增强瘤的可视化.
科学领域:
- 生物材料科学
- 纳米技术
- 化学工程
背景情况:
- 单壁碳纳米管 (SWNT) 具有独特的光学特性,适用于癌症光热疗法和生物成像等体内应用.
- 开发具有向功能的生物相容SWNT对于有效的体内癌症治疗和诊断至关重要.
- 目前的功能化策略通常会损害SWNT固有的光学特性.
研究的目的:
- 设计和合成一种新的SWNT/凝混合材料,以提高生物相容性和向癌细胞相互作用.
- 为SWNTs创建一个稳定,可操作的平台,保留它们的近红外光学特性,用于生物应用.
- 展示适用于癌症向,成像和治疗的SWNT多功能化方法.
主要方法:
- 使用碳纳米管微粒聚合,在SWNT表面创建稳定,交叉连接的聚合物凝层.
- 在凝单体中包含的maleimide组,通过反复-Diels-Alder反应以受控的功能保护.
- 通过迈克尔添加反应功能化SWNT/凝混合物,使用含醇的光染料证实.
主要成果:
- 成功合成了具有生物相容性聚合物涂层的稳定SWNT/凝混合体.
- 通过与醇化合物进行迈克尔添加反应,证明了混合物的高效和特异性功能.
- 从光染料到SWNT的成功能量转移,表明SWNT染料的成功结合.
结论:
- 开发的SWNT/凝混合平台为SWNT功能化提供了稳定和生物相容的解决方案.
- 这一策略使SWNT的光学特性得以保留,同时允许有针对性的生物结合.
- 功能化的SWNT混合体为先进的癌症向,成像和治疗应用提供了一个有前途的平台.
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