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相关概念视频

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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Planarian Ovary Dissection for Ultrastructural Analysis and Antibody Staining
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寻找平面的多能性

Tania Rozario1, Phillip A Newmark2

  • 1Morgridge Institute for Research, Madison, WI, USA.

Cell
|June 16, 2018
PubMed
概括

研究人员成功地分离出平面多能干细胞, 这一突破进一步提高了我们对干细胞生物学和组织再生的理解.

科学领域:

  • 干细胞生物学
  • 复原医学
  • 无脊椎动物学

背景情况:

  • 它们具有非凡的再生能力, 对于生存和组织修复至关重要.
  • 这些能力归功于终身多能干细胞.
  • 了解平面干细胞是释放再生潜力的关键.

研究的目的:

  • 预期分离和表征平面多能干细胞.
  • 为研究干细胞的建立,维护和激活提供基础.
  • 使用平面模型推进干细胞研究领域.

主要方法:

  • 对平面干细胞的预期隔离.
  • 使用先进的细胞生物学技术.
  • 孤立干细胞种群的特征.

主要成果:

  • 成功地将平面多能干细胞分离出来
  • 确定这些干细胞的关键标志物和特性.
  • 在体外研究这些细胞的可行性.

结论:

  • 可以实现平面干细胞的预期分离.

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  • 这种隔离有助于对干细胞调节的未来研究.
  • 开辟了理解再生的新途径.