通过极端/极端交叉进行氧中性光催化循环化
James P Phelan1, Simon B Lang1, Jordan S Compton1
1Roy and Diana Vagelos Laboratories, Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , United States.
Journal of the American Chemical Society
|June 20, 2018
概括
一种新的稳定试剂能够有效地以可见光驱动烯酸. 这种方法与多种功能组兼容,为有机合成提供了多功能工具.
科学领域:
- 有机化学
- 合成方法
- 光催化
背景情况:
- 循环化是有机合成中的关键转化.
- 开发稳定,易于使用的试剂,以实现高效的循环化仍然是活跃的研究领域.
研究的目的:
- 开发一种用于氧化还原中性循环的新型稳定试剂.
- 建立可见光介导的烯酸环化方案.
主要方法:
- 三乙二甲酸盐的合成.
- 使用可见光和有机光催化剂进行光催化环.
- 包括实验和计算分析在内的机制研究.
主要成果:
- 在多克尺度上成功合成了一种稳定的双功能试剂.
- 包括具有挑战性的基质在内的各种olefins的有效循环化在几个小时内实现.
- 反应显示高功能组耐受性和化学选择性.
结论:
- 开发的试剂和光催化方法为烯酸环化提供了一种强大而多用途的方法.
- 反应通过阴离子3-exo-tet环闭机制进行.
- 这种方法为合成复杂分子提供了显著的优势.
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