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相关概念视频

Elements and Compounds01:27

Elements and Compounds

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Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
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Periodic Classification of the Elements04:00

Periodic Classification of the Elements

59.3K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
59.3K
Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
83.3K
Classification of Elements and Compounds02:54

Classification of Elements and Compounds

73.3K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond. Elements are classified as atomic or molecular based on the nature of their basic units.
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
73.3K
Key Elements for Plant Nutrition02:35

Key Elements for Plant Nutrition

24.4K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.4K
Elements: Chemical Symbols and Isotopes02:31

Elements: Chemical Symbols and Isotopes

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A chemical symbol is an abbreviation used to indicate an element or an atom of an element. For example, the symbol for mercury is Hg. The same symbol is used to indicate one atom of mercury (microscopic domain) or to label a container of many atoms of the element mercury (macroscopic domain).
Some symbols are derived from the common English name of the element; others are abbreviations of the name in another language — Latin, Greek or German. For example, the symbol for aluminum (common name)...
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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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对类宏循环的内循环控制元件的开发

Solomon D Appavoo1, Takuya Kaji1, John R Frost1

  • 1Davenport Research Laboratories, Department of Chemistry , University of Toronto , 80 St. George Street , Toronto , Ontario M5S 3H6 , Canada.

Journal of the American Chemical Society
|June 20, 2018
PubMed
概括

研究人员开发了一种新方法来稳定循环形状,使用减少的胺键/异环 (RAH) 动机. 这种方法导致发现了向α4β7整合素的新分子.

科学领域:

  • 医学化学
  • 有机合成
  • 结构生物学

背景情况:

  • 控制宏循环构造对于发现生物活性分子至关重要.
  • 将异环结合到循环中可以稳定它们的构造.
  • 开发对形状控制的方法解决了分子设计中的挑战.

研究的目的:

  • 使用N-氨基 (Pinc) 合成具有氧化环和内循环氨基的宏环.
  • 研究循环中新型降解胺基键/异环 (RAH) 基因的构造效应.
  • 探索RAH图案在模仿生物结构和发现新药候选物的有用性.

主要方法:

  • 合成含有氧化环的宏环.
  • 可变温度核磁共振 (NMR) 分析
  • 基于核突变效应 (NOE) 的分子动力学模拟.
  • 在水溶液和DMSO溶液中进行符合性分析.

主要成果:

  • 减少的胺基键/异环 (RAH) 动机已成功安装到大环中.
  • 该RAH图案证明了在水和DMSO中稳定宏循环构造的能力.
  • 溶液结构证实了RAH图案的形状稳定作用.

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Mechanical Manipulation of Neurons to Control Axonal Development
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  • 用RAH的形状效应来模仿MAdCAM-1的二次结构.
  • 结论:

    • 在溶液中,RAH模式提供了稳定宏循环构造的有价值的策略.
    • 这种稳定解决了生物活性分子分子设计的关键问题.
    • 这项研究通过模仿生物相关的二次结构,发现了一种新的α4β7整合素抗剂.