在早期胰腺癌中,外分泌功能变化可能导致脂肪消耗
Laura V Danai1, Ana Babic2, Michael H Rosenthal2
1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nature
|June 22, 2018
概括
胰腺管腺癌 (PDAC) 是由胰腺功能下降引起的早期脂肪组织消耗. 矛盾的是,扭转这种组织损失会使小鼠的生存状况恶化,
科学领域:
- 癌症学
- 代谢综合征
- 癌症生物学
背景情况:
- 恶性病变改变宿主代谢,导致胰腺管腺癌 (PDAC) 相关的衰竭综合征.
- 由PDAC引起的周围组织损耗会对患者的生活质量和潜在的生存率产生负面影响.
- 目前针对组织消耗的循环因子的策略在临床上取得了有限的成功.
研究的目的:
- 研究早期PDAC中脂肪和肌肉组织消耗的机制.
- 确定胰腺功能和瘤位置在PDAC相关的衰竭中的作用.
- 评估扭转组织损耗对PDAC模型和患者的生存的影响.
主要方法:
- 使用PDAC的小鼠模型研究组织浪费.
- 研究瘤位置 (胰腺与非胰腺) 对脂肪组织的影响.
- 评估胰腺酶替代剂对消耗的影响.
- 分析患者在诊断时的组织枯竭数据及其与生存的相关性.
主要成果:
- 瘤在胰腺增长, 而不是其他地方, 诱导脂肪组织消耗.
- 减少胰腺外分功能被确定为脂肪组织损失的关键驱动因素.
- 胰腺酶替代疗法缓解了与PDAC相关的周围组织损耗.
- 在PDAC小鼠模型中逆转脂肪组织损失降低了生存率.
- 在PDAC患者中,在诊断时脂肪和骨肌肉组织消耗是常见的,但与生存率降低无关.
结论:
- 在PDAC中,早期的脂肪组织损失是由外分胰腺功能下降所解释的.
- 虽然在小鼠模型中逆转组织损失会损害患者的生存,但可能不会影响患者的生存.
- 这些发现提供了关于PDAC缓解症及其预后影响的见解.
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