选择酒精而不是其他奖励的分子机制
Eric Augier1, Estelle Barbier2, Russell S Dulman3
1Center for Social and Affective Neuroscience, IKE, Linköping University, Linköping, 581 83, Sweden. eric.augier@liu.se.
Science (New York, N.Y.)
|June 23, 2018
概括
研究人员发现,杏仁核中的氨酸 (GABA) 载体GAT-3的表达减少与老鼠和人类的酒精成有关. 这表明GAT-3可能是酒精使用障碍的治疗点.
科学领域:
- 神经科学
- 关于成的研究
- 分子生物学
背景情况:
- 酒精成的特点是喜欢酒精而不是自然的回报.
- 这种偏好与类似成的行为有关,包括高动力和持续使用尽管负面后果.
研究的目的:
- 调查酒精选择健康奖励背后的神经生物学机制.
- 确定治疗酒精成的潜在分子点.
主要方法:
- 通过对外生长的老鼠进行独家选择程序,以识别那些偏爱酒精而不是高价值奖励的人.
- 在偏爱酒精的老鼠和依赖酒精的人类的杏仁体中分析了GABA转运体GAT-3的表达.
- 进行了GAT-3倒置,以评估它对大鼠的选择行为的影响.
主要成果:
- 大约15%的老鼠表现出酒精偏好和类似成的特征.
- 在选择酒精的老鼠的杏仁体中观察到GAT-3表达的选择性下降.
- 这种GAT-3降低也被发现在中枢桃体的酒精依赖的人.
- 在老鼠中,GAT-3的抑制逆转了对甜食的偏好,导致老鼠选择酒精.
结论:
- 由于GAT-3表达的减少,杏仁核中的氨酸 (GABA) 清除受损导致酒精成.
- 这些发现适用于各种物种 (老鼠和人类).
- 杏仁体中的GAT-3代表了酒精使用障碍药物治疗的潜在治疗点.
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