纳米的总合成和完整的结构分配
K C Nicolaou1, Ruofan Li1, Zhaoyong Lu1
1Department of Chemistry, BioScience Research Collaborative , Rice University , 6100 Main Street , Houston , Texas 77005 , United States.
Journal of the American Chemical Society
|June 23, 2018
概括
研究人员合成了一种罕见的天然产物 - - 纳米, 这项工作澄清了它的结构,并为开发新的癌症治疗提供了材料.
科学领域:
- 有机化学
- 医学化学
- 自然产品化学
背景情况:
- 纳米是一种罕见的天然产品,具有显著的细胞毒性.
- 由于稀缺性和不确定的立体化学,其作为抗体药物联合体 (ADC) 的有效载荷被阻碍.
- 开发合成途径对于进一步的研究和应用至关重要.
研究的目的:
- 为了实现纳米的总合成,特别针对两个C7'-epimers.
- 确定纳米的完整绝对配置.
- 为未来的化学和生物研究提供基础,旨在开发新的ADC有效载荷.
主要方法:
- 两个C7'-epimers的纳米的总合成.
- 使用先进的光谱技术进行结构阐明.
- 合成化合物的立体化学分配.
主要成果:
- 两种C7'-epimers的成功合成.
- 纳米的绝对结构的完整分配.
- 有足够的数量用于进一步的研究.
结论:
- 已经完成了纳米的总合成和结构分配.
- 这项工作使得纳米作为向癌症治疗的强大ADC有效载荷的进一步探索成为可能.
- 有助于开发新的癌症治疗策略.
相关概念视频
Structures of Solids
18.0K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
18.0K
Dehydration Synthesis
150.1K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
150.1K
Ionic Crystal Structures
17.2K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
17.2K
Synthesis and Decomposition Reactions
38.3K
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes.
38.3K
Protein and Protein Structure
88.2K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
A protein's shape is critical to its function. For example, an enzyme...
88.2K
Lagging Strand Synthesis
61.4K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
61.4K


