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相关概念视频

Non-nuclear Inheritance01:29

Non-nuclear Inheritance

23.3K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
23.3K
Nuclear Fusion02:45

Nuclear Fusion

33.9K
The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
33.9K
Nuclear Stability03:18

Nuclear Stability

23.3K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.3K
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

8.8K
Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
8.8K
Nuclear Transmutation03:20

Nuclear Transmutation

20.7K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
20.7K
Nuclear Fission02:50

Nuclear Fission

12.5K
Many heavier elements with smaller binding energies per nucleon can decompose into more stable elements that have intermediate mass numbers and larger binding energies per nucleon—that is, mass numbers and binding energies per nucleon that are closer to the “peak” of the binding energy graph near 56. Sometimes neutrons are also produced. This decomposition of a large nucleus into smaller pieces is called fission. The breaking is rather random with the formation of a large...
12.5K

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相关实验视频

Updated: Feb 8, 2026

Production of Synthetic Nuclear Melt Glass
04:36

Production of Synthetic Nuclear Melt Glass

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内核膜是一个代谢活跃的区域,产生核脂滴

Anete Romanauska1, Alwin Köhler1

  • 1Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter Campus (VBC), Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria.

Cell
|June 26, 2018
PubMed
概括

内核膜 (INM) 活跃地代谢脂质,形成用于储存的核脂质滴. 这一发现将核膜代谢与基因组调节联系起来,并可能影响人类脂质变异研究.

科学领域:

  • 细胞生物学
  • 分子生物学
  • 生物化学

背景情况:

  • 内核膜 (INM) 是核外的一部分,包围着基因组.
  • 外核膜 (ONM) 连接到内质网膜 (ER),这是一个脂质合成枢纽.
  • 与ER和ONM相比,INM的代谢功能还没有得到充分了解.

研究的目的:

  • 研究内部核膜 (INM) 的代谢能力.
  • 探索INM在脂质代谢和储存中的作用.
  • 了解核脂滴形成的调节及其与基因组调节的联系.

主要方法:

  • 使用Saccharomyces cerevisiae作为一个模型生物.
  • 针对INM进行脂质代谢的已确定酶.
  • 研究核脂滴和相关膜桥的形成和功能.
  • 分析了控制核脂滴合成的遗传回路.
  • 研究了核脂滴对转录因子的隔离.

主要成果:

  • 证明INM能够进行脂质代谢和储存.
  • 表明S. cerevisiae从INM中合成核脂滴.
  • 在脂质交换中涉及的Seipin依赖膜桥.
关键词:
利宾西平甲基糖细胞内膜网内部核膜脂质新陈代谢脂质传感器核脂滴酸 酸转录因子

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Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
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相关实验视频

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Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins
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Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
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  • 发现了一种调节核脂滴合成的基因电路.
  • 发现核脂滴通过隔离转录因子来调节这种电路.
  • 结论:

    • 内核膜 (INM) 具有可适应的脂质代谢活性.
    • 核脂滴的形成与INM代谢和基因组调节有关.
    • 这些发现对理解人类脂质缩和核基因组相互作用有意义.