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Updated: Nov 29, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

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通过转基因或基因介面突变对IDH抑制获得的耐药性

Andrew M Intlekofer1,2,3,4, Alan H Shih1,2,4,5, Bo Wang1,2,6

  • 1Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature
|June 29, 2018
PubMed
概括

异酸脱酶2 (IDH2) 的体质突变导致急性髓性白血病 (AML). 新的IDH2突变可能会出现,通过激活2-基酸盐 (2HG) 产生耐药性.

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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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