光遗传编辑揭示了学习的动作序列的层次组织
Claire E Geddes1, Hao Li2, Xin Jin2
1Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
Cell
|June 30, 2018
概括
学习的动作序列是按层次排列的, 而不是按序列排列的. 基底腺
科学领域:
- 神经科学
- 行为科学
背景情况:
- 复杂的行为依赖于有组织的行动序列.
- 学习序列的控制机制仍然不清楚,关于链与等级的辩论.
- 天生的序列与中央模式生成器联系在一起,但学习的序列不太了解.
研究的目的:
- 研究学习的行动序列的组织结构.
- 确定已学习的动作序列是否以链式或等级式的方式控制.
- 在序列控制中阐明基底腺路的不同作用.
主要方法:
- 训练小鼠执行异质的动作序列.
- 使用依赖状态的闭环光遗传刺激.
- 操纵带状直接和间接路径以观察对序列执行的影响.
主要成果:
- 状直径和间接直径以不同的方式编码序列结构水平.
- 在不改变序列长度的情况下选择性地插入动作元件.
- 通过对条纹间接通路进行操纵,
结论:
- 已学会的行动序列表现出一个层次的,而不是连续的组织.
- 基底腺通路,特别是状直接和间接通路,明显地控制了这个等级的不同层次.
- 这些发现为复杂的学习行为提供了洞察力.
相关概念视频
RNA Editing
9.9K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.9K
Fixed Action Patterns
17.7K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
Organization of Genes
73.6K
Overview
73.6K
Action Potentials
142.8K
Overview
142.8K
Action Potential
4.7K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
4.7K
Action Potential
11.4K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
11.4K


