由机器人信号水平控制的胎儿皮层神经发生的演变
Adrián Cárdenas1, Ana Villalba1, Camino de Juan Romero1
1Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant, 03550 Alacant, Spain.
Cell
|July 3, 2018
概括
大脑发育的进化变化揭示了哺乳动物如何扩大大脑皮层. 关键的信号通路Slit/Robo和Dll1控制神经元的产生,
科学领域:
- 发育生物学
- 进化生物学
- 神经科学
背景情况:
- 由于神经发生的不同,爬行动物,鸟类和哺乳动物的大脑皮层大大不同.
- 虽然已知哺乳动物神经发生的途径,但它们在胚胎的进化起源尚不清楚.
研究的目的:
- 研究胚胎细胞中大脑皮层发育的进化差异的遗传和信号机制.
- 确定负责哺乳动物新皮层扩张的保存信号通路.
主要方法:
- 哺乳动物,鸟类和爬行动物的古皮质和新皮质神经发生的比较分析.
- 在小鼠,小和蛇胚胎中获得和失去功能的实验.
- 使用人类大脑器官来研究信号通路的作用.
主要成果:
- 从放射性质直接的神经发生在所有胚胎细胞中占主导地位;通过基底原生体间接的神经发生是哺乳动物新皮质的特征.
- 高Slit/Robo和低Dll1信号是直接神经发生的必要和充分条件.
- 在蛇和鸟类中调节Robo和Dll1信号可以诱导基底原生细胞形成和间接神经发生.
结论:
- 哺乳动物新皮质的进化扩张和复杂性是由保存信号通路的变化驱动的.
- Slit/Robo和Dll1信号的调节是胎儿大脑进化的关键机制.
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