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Updated: Feb 8, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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替代分离依赖REST调节的缺陷导致聋

Yoko Nakano1, Michael C Kelly2, Atteeq U Rehman3

  • 1Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Inflammation Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Cell
|July 3, 2018
PubMed
概括

通过调节毛细胞中的神经元基因表达, REST 基因的替代拼接对于听力至关重要. 这种拼接缺陷会导致老鼠和人类的聋,但HDAC抑制剂可能提供一种潜在的治疗方法.

关键词:
美国国家航空局27在 NRSF其他替代拼接耳毛细胞听力障碍基因表达的调节基脱乙酶抑制剂内部耳朵前庭毛细胞

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