控制尺寸的胺介导DNA纳米纤维生长
Danny Bousmail1, Pongphak Chidchob1, Hanadi F Sleiman1
1Department of Chemistry , McGill University , 801 Sherbrooke Street West , Montreal , QC H3A0B8 , Canada.
Journal of the American Chemical Society
|July 10, 2018
概括
研究人员使用氨酸染料单元开发了1D DNA纳米纤维. 这些功能性纳米材料可用于生物传感和向药物输送应用.
科学领域:
- 超分子化学
- 纳米材料科学
- 生物结合物化学
背景情况:
- 一维 (1D) 超分子架构对于药物输送和模板设计至关重要,因为它们的刚性和高面比.
- 开发功能性和生物相关的1D纳米结构对于材料科学和纳米医学的先进应用至关重要.
研究的目的:
- 调查 (Cy3) 染料对两动物DNA自组合的作用.
- 开发一种用于纳米医学和材料科学的功能性1DDNA纳米纤维的方法.
主要方法:
- (Cy3) 染料单元的特定位点内置到定义序列的DNA两体中.
- 使用各种技术对自组装结构的描述.
- 对刺激反应的表现和控制长度的种子生长.
- 采用金纳米颗粒和DNA原型的模板.
主要成果:
- 在水性介质中引入Cy3染料单元引发了从球体到1DDNA纳米纤维的结构过渡.
- 纳米纤维的形成取决于单元的存在和位置.
- 通过种子生长机制实现了对DNA纳米纤维的控制长度.
- 组装的纳米纤维显示出改变的Cy3染料光学特性,使纤维生长的监测成为可能.
- 通过金纳米粒子和DNA原形的模拟来证明功能化.
结论:
- 染料的结合提供了生成1D DNA纳米纤维的简单方法.
- 这些DNA纳米纤维为创建功能性纳米材料和复杂的层次架构提供了多功能平台.
- 开发的结构对生物传感和向药物输送的应用具有重大前景.
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