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相关概念视频

From DNA to Protein03:06

From DNA to Protein

22.5K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
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Encoding01:19

Encoding

867
Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
Automatic processing involves the encoding of details like time, space, frequency, and the meaning of words, usually done without conscious...
867
DNA-only Transposons02:57

DNA-only Transposons

17.5K
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
17.5K
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

16.7K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
16.7K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

14.5K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
14.5K
DNA Helicases00:55

DNA Helicases

24.2K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.2K

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相关实验视频

Updated: Feb 8, 2026

Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles
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Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles

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DNA编码的 Janus 蛋白质纳米粒子

Oliver G Hayes, Janet R McMillan, Byeongdu Lee1

  • 1X-ray Science Division , Argonne National Laboratory , Argonne , Illinois 60439 , United States.

Journal of the American Chemical Society
|July 11, 2018
PubMed
概括

研究人员使用DNA结合制造出基于蛋白质的Janus纳米粒子. 这些新型纳米粒子自组成独特的3D超级网格,使可调节的合晶体结构成为可能.

科学领域:

  • 生物技术
  • 材料科学
  • 纳米技术

背景情况:

  • 由于它们的不对称功能,
  • 合成这些非中心对称的粒子带来了重大挑战.
  • 蛋白质和DNA为纳米级工程提供了多功能平台.

研究的目的:

  • 为了合成新的基于蛋白质的Janus纳米粒子.
  • 探索这些纳米粒子如何自组合成三维超级网格.
  • 为了证明DNA介导相互作用的可调性,用于合结晶.

主要方法:

  • 利用蛋白质化学异性和DNA化学进行纳米粒子合成.
  • 用特定序列的核酸域编码蛋白质.
  • 使用直角寡核酸序列进行粒子间DNA结合.
  • 研究具有六角层架构的超级网格的自组装.

主要成果:

  • 通过DNA链接器成功合成基于蛋白质的Janus纳米粒子.
  • 形成前所未有的多元纳米粒子超级网.
  • 通过DNA键的调节来证明可调节的格子扩张.
  • 实现独特的,低对称的六角层架构.

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Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
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Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

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Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

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相关实验视频

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Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles
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Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles

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Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
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Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

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Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

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结论:

  • 基于蛋白质的Janus纳米粒子是工程结合晶体的有效构建块.
  • DNA编码的纳米粒子为先进的材料设计提供了多功能平台.
  • 这种方法为合晶体和纳米技术的应用奠定了先例.