希斯提丁代谢是甲基酸敏感性的主要决定因素
Naama Kanarek1,2,3,4, Heather R Keys1, Jason R Cantor1,2,3,4
1Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA.
Nature
|July 12, 2018
概括
希斯蒂丁降解途径影响癌细胞对甲醇的敏感性. 增强这种途径,可能是通过饮食中的histidine,可以提高化疗效率和患者的存活率.
科学领域:
- 生物化学
- 癌症学
- 遗传学
背景情况:
- 甲基是一种化学疗法药物,可抑制核酸减少酶,对核酸合成至关重要.
- 高度的甲甲毒性限制了它的有效性,需要改善癌细胞敏感性的策略.
- 鉴定调节甲醇反应的基因是提高其治疗潜力的关键.
研究的目的:
- 识别影响癌细胞对甲醇的反应的基因.
- 研究胺降解途径对甲醇敏感性的作用.
主要方法:
- 使用CRISPR-Cas9查来识别调节甲醇反应的基因.
- 在培养的癌细胞和体内白血病移植中进行了实验.
- 分析包括基因表达,细胞四酸盐水平和患者生存数据.
主要成果:
- 参与歇斯蒂丁代谢的FTCD基因被确定为甲状腺素敏感性的调节剂.
- 在基因降解途径中耗尽的基因降低了癌细胞中的甲状腺素敏感性.
- 发现西胺的代谢会耗尽四酸盐,从而加剧甲醇的作用.
- 细胞线中的胺降解增加与甲状腺素敏感性和患者存活率相关.
- 通过饮食补充希斯蒂丁可以提升体内甲状腺素的疗效.
结论:
- 希斯提丁降解途径显著影响癌细胞对甲醇的敏感性.
- 通过饮食干预来向希斯蒂丁代谢,提供了一种改善甲状腺素疗效的新方法.
- 这一发现为通过简单的代谢操作优化化疗的途径开辟了道路.
相关概念视频
Lipid Catabolism
1.0K
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
1.0K
Carbohydrate Catabolism
1.1K
Carbohydrate catabolism is a fundamental process in cellular metabolism that enables energy extraction from glucose through two primary pathways: cellular respiration and fermentation. Both pathways begin with glycolysis, which operates independently of oxygen availability.Glycolysis: A Shared Starting PointGlycolysis is an oxygen-independent process that breaks down glucose into two molecules of pyruvic acid. During this process, a net gain of two ATP molecules and two NADH molecules is...
1.1K
Amino Acid Catabolism
1.2K
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
1.2K
Types of Chemical Reactions: Anabolic and Catabolic
20.5K
The first law of thermodynamics holds that energy can neither be created nor destroyed—it can only change form. An organism's essential function is to consume (ingest) energy and molecules in the foods we eat, convert some of it into fuel for movement, sustain our body functions, and build and maintain our body structures. There are two types of reactions that accomplish this: anabolism and catabolism.
Anabolism is the process of combining smaller, simpler molecules into larger, more...
Anabolism is the process of combining smaller, simpler molecules into larger, more...
20.5K
Major Organs of the Digestive System
9.8K
The digestive system is responsible for the ingestion of food, secretion of enzymes, mixing and digesting food, absorption of the nutrients and defecation. The human digestive system consists of two major parts: the gastrointestinal tract and the accessory digestive organs.
Gastrointestinal tract:
Gastrointestinal tract:
9.8K
Major Hormones and Their Functions
2.0K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
2.0K


