在细菌中发现前所未有的素形成机制
Kenichi Matsuda1,2, Takeo Tomita1,3, Kazuo Shin-Ya1,4
1Biotechnology Research Center , The University of Tokyo , Tokyo 113-8657 , Japan.
Journal of the American Chemical Society
|July 13, 2018
概括
研究人员发现了一种新的细菌合成途径, 这一发现揭示了以前未知的细菌产生这种独特化学结合的能力.
科学领域:
- 生物化学
- 自然产品生物合成
- 微生物学
背景情况:
- 在天然产品生物合成中,-键的形成至关重要.
- 现有的知识主要集中在特定的生物合成路径上.
- 在自然界中,酸盐的生物合成在很大程度上仍未被探索.
研究的目的:
- 确定在s56-p1中产生的生物合成机制.
- 调查这种新生物合成途径的流行和起源.
主要方法:
- 与s56-p1相关的基因集群的生物信息分析.
- 跨细菌类的比较基因组学.
- 对已识别的基因卡塞特进行了基因分析.
主要成果:
- 一个独特的基因卡塞特编码机器的识别.
- 证明这个机器参与了二S56-P1的生物合成.
- 发现基因盒在多种细菌群中广泛存在.
结论:
- 已经阐明了细菌水生物合成的新途径.
- 这一发现突显了细菌在合成中所忽视的潜力.
- 这种广泛分布表明细菌水素具有重要的生态或进化作用.
更多相关视频
08:58In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
Published on: September 2, 2019
7.5K
10:28The Encapsulation of Cell-free Transcription and Translation Machinery in Vesicles for the Construction of Cellular Mimics
Published on: October 21, 2013
15.6K
相关概念视频
Protein Translocation Machinery on the ER Membrane
6.8K
The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...
6.8K
The Roles of Bacteria and Fungi in Plant Nutrition
47.4K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
47.4K
Drug Discovery: Overview
11.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
11.8K
Discharge Summary Forms
1.3K
The discharge summary is crucial as it enables a smooth transition from a healthcare facility to a patient's home or another care setting. This critical document facilitates seamless continuity of care, ensuring patients receive the necessary support and attention.
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
1.3K
Production of Formed Elements
4.8K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Most HSCs commit to...
4.8K
Cartesian Form for Vector Formulation
1.1K
The Cartesian form for vector formulation is a process to calculate the moment of force using the position and force vectors. The moment of force is defined as the cross-product of these vectors, making it a vector quantity. The Cartesian form of the position and force vectors involves unit vectors, which can be used to express the cross-product in determinant form.
1.1K
