可见光介导的转环素的生成及其在循环桥接的合成中的利用
Jon I Day1, Kamaljeet Singh1, Winston Trinh1
1107 Physical Science, Department of Chemistry , Oklahoma State University , Stillwater , Oklahoma 74078 , United States.
Journal of the American Chemical Society
|July 13, 2018
概括
研究人员开发了一种使用不稳定的转环合成的方法. 通过使用结, 它们克服了短寿命, 能够制造出独特的氧循环.
科学领域:
- 有机化学
- 合成化学
背景情况:
- 转环是高度紧张和反应性的,但由于寿命短,难以合成.
- 之前的合成应用被其不稳定性所限制.
研究的目的:
- 开发一个简单的条件来获取转环素.
- 证明转环在合成氧环乙烯中的有用性.
- 为了克服合成应用中转环的短寿命.
主要方法:
- 对cis-cyclohexene进行紫外线照射以产生trans-cyclohexene.
- 通过基质和反应伙伴之间的键进行预组织.
- 在形成氧环乙烯时使用转环素.
主要成果:
- 一个类型的转环的成功合成.
- 在形成从cis-cyclohexene中无法获得的氧环乙烯中被证明是有用的.
- 确立结合作为一种稳定转环合成的策略.
结论:
- 开发的方法提供了有价值的转环素.
- 使用这种新方法可以合成氧环乙烯.
- 通过预组织稳定转环是一种可行的合成化学策略.
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