在假心内膜炎中提高F-氧葡萄糖正电子发射断层扫描/计算机断层扫描的诊断性能
Laurens E Swart1,2, Anna Gomes3, Asbjørn M Scholtens4
1Department of Radiology and Nuclear Medicine (L.E.S., G.P.K., R.P.J.B.), Erasmus Medical Center, Rotterdam, The Netherlands.
18F-氧葡萄糖 (FDG) PET/CT为诊断假心内心炎 (PVE) 提供了很高的准确性. 排除低炎症或手术粘合剂等混因素显著提高了诊断性能,使FDG PET/CT成为一种有价值的工具.
科学领域:
- 核医学
- 心脏病学
- 传染性疾病
背景情况:
- 18F-氧葡萄糖 (FDG) PET/CT是一种用于假心内膜炎 (PVE) 的新型成像方法.
- 之前的研究显示,由于非标准化方法和混因素,诊断准确度有所变化.
- 这项研究旨在通过识别和减轻混因素来提高FDG PET/CT的性能.
研究的目的:
- 提高疑似假心内心炎 (PVE) 的FDG PET/CT诊断准确度.
- 确定和排除影响FDG PET/CT解释的混因素.
- 评估PVE检测的视觉和定量评估方法.
主要方法:
- 使用FDG PET/CT对160名疑似PVE患者和77名对照患者的回顾性分析.
- 使用视觉和定量标准化的方法对扫描进行独立的盲目重新评估.
- 用于识别和排除混变量的后勤回归.
主要成果:
- 最初的视觉评估显示PVE的灵敏度为74%和特异性为91%.
- 较低的C反应蛋白水平和手术粘合剂被确定为重要的混因素.
- 除了混剂,视觉评估的灵敏度提高到91%,特异性提高到95%.
- 标准化吸收值比率 (SUVr) ≥2. 0显示PVE的灵敏度为100%和特异性为91%.
结论:
- 在视觉和定量上,FDG PET/CT为PVE提供了高的诊断准确性.
- 建议及早实施,以避免低炎症活性的混效应.
- 而最近的门植入则不是.
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