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Updated: Feb 7, 2026

Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes
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53BP1-RIF1-shieldin通过CST和Polα依赖的填充来对抗DSB切除

Zachary Mirman1, Francisca Lottersberger1,2, Hiroyuki Takai1

  • 1Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY, USA.

Nature
|July 20, 2018
PubMed
概括

与聚合酶α一起作用的CTC1-STN1-TEN1 (CST) 综合体通过防止切除来控制DNA双链断裂的修复. 这种机制对BRCA1突变癌症至关重要.

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