在接受抗生素治疗的患者中,益生菌可预防Clostridium difficile感染
Joshua Z Goldenberg1,2, Dominik Mertz3, Bradley C Johnston4
1Bastyr University Research Institute, Kenmore, Washington.
JAMA
|July 21, 2018
概括
当与抗生素一起服用时,益生菌可能会降低Clostridium difficile感染的风险. 证据表明益生菌与安慰剂相比也与较少的不良事件有关.
科学领域:
- 微生物学
- 传染性疾病
- 胃肠病学
背景情况:
- 抗生素使用是Clostridium difficile感染 (CDI) 的一个主要危险因素.
- 益生菌是旨在提供健康益处的活微生物,通常用于恢复肠道微生物群平衡.
研究的目的:
- 评估益生菌与抗生素的同时使用是否降低了成人和儿童症状性Clostridium difficile感染的风险.
- 评估益生菌与抗生素同时使用是否会增加不良事件的风险.
主要方法:
- 随机对照试验的系统审查和元分析.
- 包括涉及成人和儿童群体的抗生素.
- 同时服用益生菌与安慰剂或没有治疗的比较.
主要成果:
- 中等质量的证据表明,益生菌与发展Clostridium difficile感染的风险显著降低.
- 非常低质量的证据表明,与安慰剂或不治疗相比,益生菌可能与较少的不良事件有关.
结论:
- 补充益生菌似乎是减少与抗生素相关的Clostridium difficile感染的安全和有效策略.
- 需要进一步进行高质量的研究来证实益生菌的安全性,并充分阐明益生菌在这种情况下所带来的益处.
更多相关视频
相关概念视频
Healthcare Associated Infections II: Preventive Measures
4.1K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.1K
Antibiotic Selection
60.0K
Overview
60.0K
Receiver Operating Characteristic Plot
490
A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
490
Cancer Prevention
8.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
8.1K
Prevention of Further Absorption of Poison
1.3K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.3K
Preventive Healthcare Services
2.2K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
2.2K


