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对于对模拟敏感的TET氧基酶的蛋白质 - 连接器接口的补充固体工程

Babu Sudhamalla1, Sinan Wang1, Valerie Snyder1

  • 1Department of Chemistry , University of Pittsburgh , Pittsburgh , Pennsylvania 15260 , United States.

Journal of the American Chemical Society
|July 21, 2018
PubMed
概括

研究人员设计了十一转位 (TET) 酶以创建对模拟敏感的变体. 这允许特异性抑制TET2,使得人类细胞中DNA细胞酶甲基化的条件调节.

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