新生猪心脏的再生潜力
Wuqiang Zhu1, Eric Zhang1, Meng Zhao1
1Department of Biomedical Engineering, School of Medicine, and School of Engineering (W.Z., E.Z., M.Z., C.F., Y.T., J.D.H., A.V.B., G.P.W., G.Q., J.Z.), University of Alabama at Birmingham.
Circulation
|July 22, 2018
概括
新生猪在生命的头两天内可以在受伤后再生心肌. 这种心脏再生能力与心肌细胞的增殖有关,并且在出生后很快就消失了.
科学领域:
- 心血管研究
- 新生儿生理学
- 复原医学
背景情况:
- 动物的心脏在出生后的7天内表现出心肌再生.
- 大型哺乳动物心肌再生的可能性尚不清楚.
研究的目的:
- 研究新生大哺乳动物心肌再生的窗口.
- 确定新生猪在心肌梗塞后是否表现出心脏再生能力.
主要方法:
- 新生猪的手术诱导急性心肌梗塞 (AMI) 在出生后的几天 (P1,P2,P3,P7,P14).
- 评估心脏缩功能,心肌细胞循环活动,心脏病发作大小和端粒酶活性.
- 通过心声学和组织学分析评估了AMI后30天的结果.
主要成果:
- 在P1组显著恢复缩功能,在P2组在AMI后30天恢复部分功能.
- 在产后3天或更晚时诱导AMI时观察到缩功能受损.
- 在AMI后,P1心脏表现出最小的痕和心肌细胞循环活动增加.
结论:
- 新生猪的心脏可以在生命的头2天内在AMI后再生.
- 心肌细胞的增殖是这种再生能力的基础.
- 随着心肌细胞在出生后不久离开细胞循环,
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